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Metabolomic profiling reveals altered phenylalanine metabolism in Parkinson’s disease in an Egyptian cohort
Shebl, N El-Jaafary, S Saeed, AA Elkafrawy, P El-Sayed, A Shamma, S Elnemr, R Mekky, J Mohamed, L Kittaneh, O
Shebl, N
El-Jaafary, S
Saeed, AA
Elkafrawy, P
El-Sayed, A
Shamma, S
Elnemr, R
Mekky, J
Mohamed, L
Kittaneh, O
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Date
2024-03-07
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Abstract
Parkinson’s disease (PD) is the most common motor neurodegenerative disease worldwide. Given the complexity of PD etiology and the different metabolic derangements correlated to the disease, metabolomics profiling of patients is a helpful tool to identify patho-mechanistic pathways for the disease development. Dopamine metabolism has been the target of several previous studies, of which some have reported lower phenylalanine and tyrosine levels in PD patients compared to controls.
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American University of Cairo